The San Francisco 49ers (4-3) visit the NFC West rival Seattle Seahawks (5-1) Sunday of Week 8 for a 4:25 p.m. ET kickoff at CenturyLink Field. Below, we preview the 49ers-Seahawks betting odds and lines and make our NFL picks and predictions.

The betting odds will grow progressively longer until you reach the rank outsider. The Kansas City Chiefs are the +600 favorites in the Super Bowl odds, followed by the Ravens, 49ers. The Chiefs are listed at 6/1 odds (Bet $100 to win $600), while the defending champion Buccaneers are the third-betting choice at 10/1. In between Kansas City and Tampa Bay are the Green Bay Packers, who are currently at 9/1 odds. Here is a quick reference on Super Bowl odds for the upcoming 2021 NFL season. How to read NFL Las Vegas Odds.

49ers at Seahawks betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 11:37 a.m. ET.

Money line:

Betting On The San Francisco 49ers To Win Super Bowl 2020. Those who took a chance betting on the San Francisco 49ers to win Super Bowl 2020 at the beginning of the season are smiling from ear to ear. Coming in under the radar, the Niners have become one of the most dominant teams of this NFL season.

49ers +130 (bet $100 to win $130) Seahawks -152 (bet $152 to win $100)Against the spread/ATS: 49ers +3 (-115) Seahawks -3 (-106)Over/Under: 53.5 (O: -110 U: -110)

Special NFL Week 8 Betting Promotion

Bet $1 on ANY TEAM’S money line Sunday, WIN $100 (in free bets) if any team scores a touchdown during Sunday’s NFL action.

Place your legal, online sports bets in CO, IN, NJ, TN and WV at BetMGM, The King of Sportsbooks! Terms and conditions apply. Bet now!

49ers at Seahawks game notes

The 49ers enter on a two-game win streak following a 33-6 rout of the New England Patriots on the road. The 49ers, who were a 3-point dog, outgained the Pats 467 total yards to 241, while the defense finished with four interceptions. San Francisco QB Jimmy Garopollo was an impressive 20 of 25 for 277 passing yards, but he was picked off twice.Seattle lost its first game of the season, falling to the Arizona Cardinals 37-34 in overtime last Sunday night. QB Russell Wilson threw for 388 yards (33 of 50), but was picked off three times, including an interception in overtime. WR Tyler Lockett caught all three of Wilson’s TD passes and finished with 15 receptions for 200 yards. The Seahawks were 3.5-point favorites.The 49ers are 4-3 ATS, while the Seahawks are 4-2 ATS.San Francisco owns a 3-4 O/U record, averaging 25.5 points per game. On the defensive end, the 49ers allow just 19.5 PPG to rank fifth in the league.Seattle is 4-2 O/U and leads the league in scoring (33.8) and total yards (425.2) per game. The defense yields 28.7 PPG.The rivals split their two games last season with Seattle winning at San Francisco 27-24 in overtime on Nov. 11 in what could be considered the game of the year. The 49ers responded by winning in Seattle 26-21 seven weeks later.

49ers at Seahawks key injuries

49ers

LB Kwon Alexander (ankle) doubtfulWR Richie James (ankle) doubtfulWR Deebo Samuel (hamstring) outDL Kentavius Street (illness) questionableS Jaquiski Tartt (groin) doubtfulS Jimmie Ward (quadriceps) questionableRB Jeff Wilson Jr. (ankle) out/IR

Seahawks

S Jamal Adams (groin/illness) questionableRB Chris Carson (foot) questionableCB Shaquill Griffin (concussion/hamstring) outRB Carlos Hyde (hamstring) doubtfulG Mike Iupati (back) doubtfulDE Benson Mayowa (ankle) questionableS Ugo Amadi (hamstring) doubtfulCB Ryan Neal (hamstring) questionableRB Travis Homer (knee) questionable

49ers at Seahawks: Odds, prediction, betting lines and picks

Niners Game Betting Odds

Prediction

Niners Packers Betting Odds

Seahawks 28, 49ers 23

Money line (?)

While I have the Seahawks (-152) winning, I’m going to PASS and focus on the spread.

Against the spread (?)

The SEAHAWKS -3 (-106) are the way to go. Don’t play if the line climbs to -3.5 or higher. If it drops to -2.5, which I doubt it will, it becomes my STRONGEST PLAY – 1.5 times your usual wager.

Seattle will have had a full week to think about how it blew the 10-point, fourth-quarter lead at Arizona. Wilson & Co. will be focused and will not lose back-to-back.

Over/Under (?)

This is a tough call. As mentioned, the Seahawks feature the best offense in the league and the 49ers defense ranks fifth. I’m calling for a small play on the UNDER 53.5 (-110) – half your usual wager. Don’t play if the line drops to 52.5 or lower.

Want action on this NFL game? Sign up and bet at BetMGM. If you’re looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.

Green Bay Vs Niners Betting Odds

Johnny’s 2020 NFL record / Strongest plays	2-5-1 / 1-2-1
2019 NFL record / Strongest plays	17-10-1 / 7-4
2020 overall record (all sports)	129-99-3
Strongest plays (all sports)	65-37-1

Follow @JohnnyParlay11 on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Also see:

49ers jump 4 spots in NFL Wire power rankings (Niners Wire)How Dunlap trade can save Seattle’s season (Seahawks Wire)

Seahawks Betting Odds

Gannett may earn revenue from audience referrals to betting services. Newsrooms are independent of this relationship and there is no influence on news coverage.